Chiado and Príncipe Real are the most stylish neighborhoods — elegant boutique hotels, great restaurants and cafes, close to major sights. Alfama suits those wanting traditional atmosphere but is hilly and has less nightlife. Mouraria is increasingly trendy and very local-feeling. Bairro Alto is the nightlife district — central but noisy on weekends.
Belém is tranquil and ideal for those focused on the Jerónimos and Tower, but requires a tram or Uber to reach central Lisbon. Santos and Alcântara are up-and-coming with design hotels near LX Factory. Avoid Cais do Sodré for the quietest nights. Budget guesthouses cluster around the Rossio and Intendente areas.